Narrative

Dr. Koelle studies the ecological, evolutionary, and within-host dynamics of RNA viruses affecting humans using quantitative approaches. These quantitative approaches include the development and simulation of mathematical models, as well as statistically fitting these models to data. Dr. Koelle’s research program spans four topics of inquiry: (1) Understanding the interplay between viral evolution and the epidemiological spread of viral infectious diseases. (2) Understanding constraints on viral adaptation. (3) Understanding interindividual variation in within-host viral dynamics and evolution. (4) Understanding the impact of control measures of the epidemiological and evolutionary dynamics of viral infectious diseases.